Selection of abstracts

April 18

Bloodstream infections: fast diagnosis using molecular tools

P0175 - Comparison of Molecular Rapid Diagnostic Testing Panels for Gram-negative Bacteremia using Desirability of Outcome Ranking Management of Antimicrobial Therapy (DOOR-MAT)

P0176 - Comparison of Three Rapid Diagnostic Blood Culture Identification Panels for Gram-Negative Bloodstream Infections

P0178 - Detection of Enterobacterales and associated antimicrobial resistance genes with the BIOFIRE FILMARAY Blood Culture Identification 2 (BCID2) panel

P0186 - Multi-center Evaluation of the BIOFIRE® FILMARRAY® Blood Culture Identification 2 Panel for the Detection of Microorganisms and Resistance Markers in Positive Blood Cultures

P0189 - Resolution of Discrepant Results Observed during the Clinical Evaluation of Investigational Use Only Prototype of the BIOFIRE® FILMARRAY® Blood Culture Identification 2 (BCID2) Panel

P0193 - The use and impact of a rapid molecular assay in the diagnosis and management of bloodstream infections in Botswana: a prospective clinical trial

P0233 - Identification of central nervous system infection in children without cerebrospinal fluid pleocytosis using a syndromic meningitis/ encephalitis panel

P0234 - Impact of a multiplex PCR in the management of viral meningitis

Commercial AST methods: what's new?

P0291 - Detection of colistin resistance in Pseudomonas and Acinetobacter by the ATB™ PSE EU strips

P0293 - ETEST® Eravacycline for Antimicrobial Susceptibility Testing of Enterobacteriaceae and Enterococcus spp.: performance results from a multi-centre study

P0294 - ETEST® Imipenem/Relebactam for Antimicrobial Susceptibility testing of Enterobacteriaceae and Pseudomonas aeruginosa: performance results from a multi-centre study

P0302 - Luminogenic phosphatase substrate for rapid susceptibility testing of Gram positive strains

P0304 - Multi-centre study performance results of ETEST® Delafloxacin for antimicrobial susceptibility testing against Gram-positive organisms and Pseudomonas aeruginosa

Early life infections: what, when and how?

O0274 - Type I interferon in viral and bacterial infections in children

Evaluating host responses to diagnose infection

P0458 - Comparison of host immune responses in vivo versus ex vivo lipopolysaccharide stimulation in humans using an immune transcriptomic profiling panel

P0466 - The REAnimation Low Immune Status Markers study: phenotypic and functional alterations of innate immune response in critically ill patients

Gastrointestinal infections and molecular diagnosis

P0510 - Evaluation of the BIOFIRE® FILMARRAY® GI Panel in the microbiological diagnosis and management of the patient with infectious gastroenteritis

P0517 - Prospective evaluation of three rapid multiplex PCR assays for the detection of gastrointestinal pathogens from stool samples

Gram-negatives behaving badly: antimicrobial resistance in non-enteric GNR

P0529 - European survey of Helicobacter pylori primary resistance to antibiotics: evolution over the last 20 years

Healthcare-associated pneumonia

P0555 - INHALE WP2: Health Economics of Nosocomial Pneumonia in UK Intensive Care Units (ICU): an exploratory study

Increasing knowledge on NTMs

P0618 - Compatibility of the new NTM Elite agar with MALDI-TOF for direct isolation and identification of non-tuberculous mycobacteria

P0621 - Decontamination strategies used for AFB culture significantly reduce the viability of Mycobacterium abscessus in sputum samples from patients with cystic fibrosis

P0629 - Genomic identification of clinically relevant Mycobacterium species by target sequencing

P0648 - Performance comparison between Rapidly Growing Mycobacteria medium for direct isolation of non-tuberculous mycobacteria, and its industrial version

Predicting resistance from whole genome analysis

O0236 - Impact of lung transplantation on the phylogenetic diversity of Pseudomonas aeruginosa isolates from end-stage cystic fibrosis patients

Update on surveillance of Gram-positive bacteria

P1036 - Rapid detection of Methicillin-Resistant Staphylococcus aureus in patients with late hospital acquired/ventilator associated pneumonia

We are not alone: One Health in AMR

O0106 - Colistin-resistant Enterobacteriaceae in Belgian broiler and pig farms

O0107 - Tracing of ESBL-producing and ciprofloxacin-resistant Escherichia coli in Belgian broiler and pig farms: a longitudinal study

Whole genome sequencing: from molecular characterization to typing

P1130 - Relatedness of European C. difficile strains from humans, food and animals by whole genome sequencing, ribotyping and toxinotyping; results from COMBACTE-CDI

May 18

Bloodstream infections: fast diagnosis using molecular tools

P0174 - Analytical performance evaluation of the BIOFIRE® Blood Culture Identification 2 (BCID2) Panel

P0181 - Evaluation of an investigation-use-only prototype of the BIOFIRE® Blood Culture Identification 2 (BCID2) Panel for detection of bacteria, yeast, and antimicrobial resistance markers from positive blood cultures

P0184 - Impact of the BIOFIRE® Blood Culture Identification (BCID) Panel compared to VITEK-MS and the VITEK-2 ID/AST instrument in the diagnosis and management of bloodstream infections in a 24-hour laboratory setting

P0191 - The comparison of the rapid blood identification results within/after 8 hours from positive signal of blood culture bottle

Central nervous system infections

P0220 - Clinical utility of syndromic meningitis/encephalitis testing in children

P0226 - Discrepancy results with Meningitis/Encephalitis panel BIOFIRE® in cerebrospinal fluid

P0239 - Performance of the rapid molecular assay BIOFIRE® Meningitis/Encephalitis (ME) Panel for the diagnosis of CNS infections: a one-year evaluation in a tertiary care hospital

P0243 - Rapid syndromic panel for the diagnosis of infectious meningitis and encephalitis: a systematic review and meta-analysis of accuracy

P0246 - Two-year experience of meningitis/encephalitis multiplex PCR assay on cerebrospinal fluids in comparison with conventional methods: advantages and disadvantages

P0247 - Unexpectedly high false positive Haemophilus influenzae rates using a meningoencephalitis syndromic PCR panel in two tertiary centres

Diagnostic aspects of non-flu respiratory viruses

P3685 - The clinical application of BIOFIRE® Respiratory Panel in children with acute respiratory tract infections

P0560 - Preliminary results for the evaluation of the impact of syndromic lower respiratory tract panel on antimicrobial management and infection control

JARMILA JELÍNKOVÁ MEMORIAL SESSION - Early life infections: what, when and how?

O0277 - Impact of the BIOFIRE® Gastrointestinal (GI) polymerase chain reaction panel on the clinical management of children with suspected acute bacterial – diarrhoea

O0394 - The effects of introduction of a syndromic PCR sputum testing in intensive care unit pneumonia patients in a tertiary trauma centre

P4377 - Evaluation of a quantitative multiplex PCR panel for the diagnosis of pneumonia: how do we optimise utilisation?

P4382 - Impact assessment of the results of BIOFIRE® Pneumonia plus Panel for the detection of pathogenic bacteria and individualised therapeutic targeting

P4383 - Impact of respiratory panel PCR assay on antibiotic use in patients with community-acquired pneumonia admitted to intensive care unit

P4384 - Laboratory evaluation of the BIOFIRE® Pneumonia plus Panel compared to standard-of-care testing at a private laboratory in Cape Town, South Africa

P4387 - Microbiological validation of the BIOFIRE® Pneumonia plus Panel: a single-centre experience

P4395 - The potential impact of molecular rapid identification of pneumonia by the BIOFIRE® Pneumonia plus Panel on antimicrobial stewardship and patient management at a large district general hospital, United Kingdom

Travel medicine and migrant health

P4471 - Multiplex PCR for the detection of traveller’s diarrhoea: a nested case-control study

Viral respiratory infections

O0766 - Too much of a good thing? Evaluation of respiratory viral panel usage in paediatric bone marrow transplant patients

April 19

- Advancing care levels through decentralization of respiratory testing within the hospital

- Bloodstream Infections: how rapid molecular diagnostic can improve patients management

- Is it time to stop, change or continue antibiotics? Becoming comfortable with rapid syndromic testing of pneumonia patients

An ever-looming threat: infections in immunocompromised hosts

O0363 - Burden of Viral Infections among Autologous Stem Cell Transplant Patients: A Prospective Longitudinal Study

Antimicrobial Resistance: moving from action plans to implementation, a Global perspective

I134 - Antimicrobial Stewardship and rapid diagnostics for better prescribing: a UK perspective

I131 - Light in the face of Darkness, the critical role of a Clinical Microbiologist in AMS in the South African landscape

I133 - The pivotal role of the clinical microbiologist in implementing an AMR National Action Plan : an Italian experience

I132 - Using Diagnostics to Advance Antimicrobial Stewardship in Canada

Bloodstream infections: be "positive"

P1704 - Evaluation of the Expanded-Coverage Staphylococcus Species Assays and Improved Methicillin Resistance Detection Algorithms of the BIOFIRE® FILMARRAY® Blood Culture Identification 2 (BCID2) Panel

Culture-based approaches for carbapenemase screening and confirmation

P1765 - Evaluation of the performance of three chromogenic culture media for the detection of carbapenemase producing Enterobacterales to manage healthcare-associated infections

Current challenges in laboratory automation

P1779 - Evaluation of Colibrí™ for antimicrobial susceptibility testing

P1780 - Evaluation of Colibrí™ for the identification of Gram negative bacilli

P1790 - PhenoMATRIX™ TAG and Colibrí™ for a faster workflow of the management of urine specimens

Diagnosing bloodstream infection

P1825 - Evaluation of the BACT/ALERT® VIRTUO™ in terms of time to detection, performance, workflow efficiency and impact on patient management, compared to the BACTEC™ FX automated blood culture system

Metagenomics goes clinical

P1312 - Comparative analysis of kitome identification methods in viral metagenomic data

Molecular testing and multiplex panel approaches for diagnosis

O0393 - Assessing impact of Multiplex PCR point of care testing in patients with respiratory tract infection: a French national study

Opportunities and tools to change prescribing behaviour

P2059 - INHALE WP4: Antibiotic Prescribing Decisions in Intensive Care: A Qualitative Study

State-of-the-art detection of carbapenemases and colistin resistance

O0535 - Rapid detection of colistin resistance using a newly developed protocol for MALDI-TOF Mass Spectrometry

April 20

Antimicrobial resistance in animals, food and beyond

P2376 - High-level AmpC beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Dutch hospitals and livestock farms: results from the i-4-1-Health project

Bone and joint infections

P2436 - Evaluation of the BIOFIRE® FILMARRAY® Bone and Joint Infection (BJI) Panel for the detection of microorganisms and resistance markers in synovial fluid specimens

Clinical challenges and culture-based diagnostics

P2909 - Efficient inactivation of clinically relevant antimicrobial drug concentrations by two resin-containing media in simulated paediatric blood cultures

P2407 - Performance of the NTM Elite agar* for the detection of non-tuberculous mycobacteria in sputum samples of patients with cystic fibrosis

Food, water and environmental safety

O0726 - Colistin-resistant bacteria in indian raw food samples

Markers and scores for sepsis

P3053 - Human Endogenous Retroviruses as markers of severity in Sepsis

P3058 - The REAnimation Low Immune Status Markers study: phenotypic and functional alterations of adaptive immune response in critically ill patients

Mass spectrometry for microbial detection, identification and typing

P3074 - Differentiation of the members of the Staphylococcus aureus complex by MALDI -TOF using the VITEK® MS platform

P3070 - Genomic characterization of Achromobacter strains by nrdA gene analysis

Molecular diagnosis of genital infections

P3110 - MYCOPLASMA IST3, a new in vitro medical device to aid the diagnosis of urogenital mycoplasma infection: performance results from an international multi-center trial

Molecular tools for bacterial diagnosis: how, when and why to use them?

O0888 - Syndromic tests for meningitis: patient screening before testing allows a high efficient medical value

Optimised prescribing through diagnostics

O0814 - High clinical impact on antimicrobial stewardship using multiplex PCR syndromic panels for severe community acquired infections: a real life experience

The changing scenario of Candida infections

P2779 - Not all candidaemias are the same: utility of a rapid identification

April 21

Advances in understanding the epidemiology of HAI

O1218 - Differences in risk and outcomes for patients with Clostridium difficile toxin positive versus only cytotoxigenic culture positive faecal samples; results from COMBACTE-CDI case/control study

Improving diagnostics in the fungal field

O1260 - Differentiation at species level of the members of the PSC complex (Pseudallescheria boydii/Scedosporium apiospermum) involved in cystic fibrosis by MALDI-TOF MS (VITEK MS®)

MIC: are all methods equal

P4085 - Performance of VITEK® 2 AST-GN Meropenem/Vaborbactam for Antimicrobial Susceptibility Testing of Enterobacteriaceae and Pseudomonas aeruginosa: A Multi-Center Study

Molecular epidemiology and detection of resistant staphylococci

O1232 - An emerging Methicillin Resistance Mechanism due to loss of function of the GdpP protein in mec Gene Negative Staphylococci undetected by Reference Methods

PS129 - Antibiotic hospital consumption measurements around the world

P3458 - 1. Nigeria – The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS): Roll out of a successful antimicrobial stewardship program in Nigeria using the global-PPS tool

P3460 - 2. Brazil – Trends in Antimicrobial Use in Brazilian Hospitals: 2017 and 2018 Point Prevalence Surveys

P3459 - 3. Guinea – The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS): The Results of Antimicrobial prescribing in 33 hospitals in Guinea

P3459 - 4. Belgium – The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS): an opportunity to lead global stewardship actions in Belgian hospitals ?

P3457 - 5. Ghana – The Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS): Results of Antimicrobial Prescribing at Ghana’s National Referral Centre

P3453 - 6. Chile – Improving Country-Level Antimicrobial Prescribing with the implementation of a uniform and standardised surveillance method. The Global PPS Chilean experience, year 2015 and 2017

Respiratory infections: what to expect from molecular tools?

P4375 - BIOFIRE® FILMARRAY® Pneumonia Panel in the evaluation of severe lower respiratory tract infections

P4378 - Evaluation of BIOFIRE® FILMARRAY® Pneumonia Plus for the detection of pathogen bacteria in respiratory infections

P4379 - Evaluation of the BIOFIRE® FILMARRAY® Pneumonia plus Panel for Rapid Diagnosis of Hospital-Acquired Pneumonia

P4380 - Evaluation of the potential clinical impact of BIOFIRE® FILMARRAY® Pneumonia Plus Panel for the treatment of VAP in ICUs patients, Careggi University Hospital, Florence

P4385 - Microbiological performances and clinical impact of the BIOFIRE® FILMARRAY® Pneumonia Plus Panel on critically ill with severe pneumonia

P4386 - Microbiological Point-of-Care analysis of endotracheal aspirate from intubated patients admitted to the intensive care unit

P4388 - Multicentre study for the evaluation of BIOFIRE® FILMARRAY® Pneumonia Plus Panel for the rapid microbiological diagnosis of low respiratory tract infections

P4389 - Multinational Performance Evaluation of the BIOFIRE® FILMARRAY® Pneumonia plus Panel

P4392 - Performance of a PCR-based syndromic panel compared to routine culture and microscopy in patients suspected of pneumonia

P4394 - The INHALE trial: designing a prescribing algorithm to aid antibiotic choices for the BIOFIRE® FILMARRAY® Pneumonia plus (PNplus) Panel